You say that the number of consecutive hours of low insulin is what might matter. But on alternate-day fasting regimens, insulin levels are low for up to 36 hours consecutively. In rodents, we know that this is long enough to get an extension in longevity. Why do you think that 20 hours of low insulin with a CC diet is long enough to get the same effect?

The main reason we are advocating a CC diet rather than an alternate day diet is that we judge it as much more feasible for large numbers of humans to maintain indefinitely. Moreover, we are emphasizing healthy aging rather than longevity and we believe this will work based on much work related to low insulin diets (see next question). Of course, we don’t know for sure how well it will work and no one will have a definitive answer on this for some time. But one way we might evaluate this experimentally is to look at the impact of blood serum derived from people engaged in specific diets on certain longevity markers in cultured human cells incubated with that serum. This is a strategy pioneered by researchers at the National Institute of Aging (NIH), and there is no reason why we couldn’t compare the effects of serum from people on CC diets with those of serum from people who are doing calorie restriction or intermittent fasting.

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