Tributyrin May Have Practical Potential for Improving Cognition in Early Alzheimer’s Disease Via Inhibition of HDAC2

Recent research at MIT has determined that, in rodent models of Alzheimer’s dementia, the negative impact of amyloid beta exposure on neuronal function and new memory formation results largely from increased neuronal expression of an enzyme known as HDAC2 (histone deacetylase 2). A class of drugs and metabolites known as class I histone deacetylase inhibitors have the potential to inhibit the activity of HDAC6 and thereby favorably impact memory. This article reviews those drugs, and suggests that, in light of the high cost of certain other options, an approved food additive known as tributyrin may have the most practical potential in this regard.

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