Strategies for Controlling Serum Amyloid A, a Key Mediator of the Impact of Systemic Inflammation on Cardiovascular Disease

Although a systemic inflammatory state associated with elevated C-reactive protein (CRP) is clearly associated with increased cardiovascular risk, CRP per se does not appear to mediate this association. There is better reason to suspect that elevated serum amyloid A – like CRP, an “acute phase reactant” produced by the liver – is a true cause of cardiovascular disease. This essay suggests that the liver’s production of serum amyloid A could be suppressed by various agents, including spirulina, salsalate, metformin or berberine, and tocotrienols.

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