NADPH Oxidase as a Mediator of Calcium Oxalate Nephrolithiasis

The most common type of kidney stone is composed of calcium oxalate. Oxalate can act on the kidney tubules to induce oxidative stress via NADPH oxidase, and this plays a role in the promotion of stone formation. This explains why phycocyanin from spirulina has shown value for preventing calcium oxalate stones in rodent studies.

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