Memo: Is Peroxynitrite a Mediator of Survival and Aggressive Growth in Pancreatic Adenocarcinoma?

Pancreatic adenocarcinomas tend to generate both superoxide and nitric oxide, and both of these factors aid the survival and spread of the cancer. This essay raises the possibility that a portion of this effect is mediated by peroxynitrite, which forms spontaneously when superoxide and nitric oxide react. If so, high-dose folate might be useful for treating this cancer, as intracellularly folates can scavenge radicals derived from peroxynitrite. Spirualina also may be helpful, by inhibiting the enzymatic complex that is the chief source of the superoxide.

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