I’ve read that reduced IGF-I activity is the real reason why calorie-restricted diets increase longevity and prevent or postpone cancer. Yet you say little about IGF-I. Will a CC diet reduce IGF-I levels?

Not necessarily. But what is important is IGF-I bioactivity. Because CC diets keep insulin low most of the day, the liver makes more of a protein called IGFBP-1 that binds to the IGF-I in the blood and prevents it from interacting with its receptor. So IGF-I activity should go down even if the IGF-I level doesn’t . And it seems likely that even the level of IGF-I will go down on a CC diet if it is vegan (plant-based and moderate in protein content).

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