Dietary Nitrate May Aid Prevention of Neovascular Age-related Macular Degeneration by Suppressing the Transcriptional Activity of Hypoxia-Inducible Factor-1 and Aiding Choroidal Perfusion

A high daily intake of spinach or collard greens has been linked to a considerable decrease in risk for age-related macular degeneration, chief cause of partial blindness in the elderly. Although the lutein content of these vegetables is thought to be largely responsible for this protection, this essay proposes that the nitrate content of these vegetables may also play a role in this protection, and suggests a mechanism that might account for this.

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