Author Archives: McCarty

Serum Bilirubin May Serve as a Marker for Increased Heme Oxygenase Activity and Inducibility in Tissues – a Rationale for the Versatile Health Protection Associated with Elevated Plasma Bilirubin

Elevated serum levels of the antioxidant bilirubin tend to be associated with lower risk for cardiovascular disease and many other disorders, but people who have elevated bilirubin owing to their expression of a low-activity form of an enzyme that aids … More scientific detail

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Targeting Adipocytes in Metabolic Syndrome – Spirulina and Salsalate May Complement the Benefits of PPARgamma Agonists

Metabolic syndrome, an important cause of vascular disease and type 2 diabetes, and a risk factor for cancer, is driven by an inflammatory state that arises in overstuffed fat cells (adipocytes). The diabetes drug pioglitazone (Actos) is useful for dampening … More scientific detail

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Strategies for Controlling Serum Amyloid A, a Key Mediator of the Impact of Systemic Inflammation on Cardiovascular Disease

Although a systemic inflammatory state associated with elevated C-reactive protein (CRP) is clearly associated with increased cardiovascular risk, CRP per se does not appear to mediate this association. There is better reason to suspect that elevated serum amyloid A – … More scientific detail

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Folate Deprivation/Antagonist Therapy for Early Stage Prostate Cancer

Prostate epithelium, and some early prostate cancers, appear to require higher concentrations of folic acid than most other tissues to support a maximal rate of cellular multiplication. Therefore, a low-folate diet and/or low doses of the folate antagonist methotrexate may … More scientific detail

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High-Dose Statin Flash-Potentiation of Cancer Chemotherapy

Concentrations of statins much higher than those achieved clinically have potentiated the cancer-killling efficacy of many cytotoxic chemotherapeutic agents in cell culture studies or mice, but would be toxic if sustained in humans. This essay proposes that administration of very-high-dose … More scientific detail

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Age-Related Macular Degeneration – Potential Roles for Nutraceuticals in its Prevention and Control

Age-related macular degeneration (AMD) is the leading cause of partial blindness in the elderly. This essay reviews what is known of its origins, emphasizing evidence that oxidative stress is a key mediator of this syndrome, and summarizing evidence that fish … More scientific detail

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NADPH Oxidase May be a Primary Mediator of the Adverse Effects of Cigarette Smoke and of Complement Activation on Retinal Pigment Epithelium during Induction of Age-Related Macular Degeneration

Retinal pigmented epithelial (RPE) cells play a number of crucial roles in supporting healthful function of the retina. Oxidative stress in RPE cells is suspected to be a key factor in the onset of age-related macular degeneration (AMD), but the … More scientific detail

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Adjuvant Strategies for Managing ALS

Amyotrophic lateral sclerosis (ALS) is a devastating and mysterious neurological disease in which the central nervous system gradually loses control of the body’s musculature, owing to progressive death of the motor neurons controlling muscles. Although no cure for this disorder … More scientific detail

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Roles of Oxidative Stress in the Pathogenesis of Hepatitis C – Implications for Full-Spectrum Antioxidant Therapy with Phlebotomy

Although our capacity to detect hepatitis C in the blood has greatly reduced transmission of this disorder via blood transfusion, this infection is still very common worldwide, and remains the leading reason for liver transplantation in the U.S. There is … More scientific detail

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A Potential Role for Spirulina in the Prevention and Management of Preeclampsia

Preeclampsia, a disorder of pregnancy in which the placenta fails to form properly, is a leading cause of fetal prematurity, growth retardation, and mortality, and can even endanger the life of the mother if not treated properly. Oxidative stress, within … More scientific detail

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Novel Prospects for Managing Cystic Fibrosis<

Cystic fibrosis (CF) is the most common genetic disorder in Caucasians that ultimately leads to premature death. Owing to genetic absence of a functional chloride channel, patients with cystic fibrosis experience chronic lung inflammation, mucus obstructions, and frequent lung infections, … More scientific detail

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High-Salt, Low-Potassium Diets May Increase Risk for Type 2 Diabetes via Marinobufagenin-Mediated Potentiation of Glucolipotoxicity in Pancreatic Beta Cells

A couple of recent Finnish epidemiological studies have yielded that novel conclusion that a high-salt diet may increase risk for type 2 diabetes. This article proposes that high salt intakes in salt-sensitive subjects, by increasing the production of a pro-oxidant … More scientific detail

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Nutraceutical Strategies for Controlling the Secretory Phenotype Associated with Cellular Senescence

As we get older, our body’s harbor an increased number of “senescent” cells no longer capable of dividing. These cells tend to secrete pro-inflammatory hormones which may contribute to the cancer induction and inflammation linked to the aging process. This … More scientific detail

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Full-Spectrum Antioxidant Therapy – Minimizing the Contribution of Oxidative Stress to Disease and Aging

This monograph proposes an integrated strategy for controlling oxidative stress using complementary nutraceuticals. Highlights the likely utility of spirulina, astaxanthin, high-dose folate, phase 2 inducers (such as lipoic acid or green tea polyphenols), melatonin, and N-acetylcysteine.

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Diet/Lifestyle Strategies for Preventing Benign Prostatic Hyperplasia

Cites evidence that this syndrome, often thought to be an inevitable concomitant of aging, was in fact once rare in elderly East Asians. Suggests that low growth factor activities associated with plant-based diets and a low-insulin lifestyle may have been … More scientific detail

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Nutraceutical Strategies for Preserving Cartilage in Osteoarthritis

The loss of cartilage associated the osteoarthritis reflects an inflammatory process that promotes degradation of cartilage proteins. This essay proposes that a number of nutraceuticals – spirulina, phase 2 inducers, berberine, glucosamine, vitamin D, and fish oil – have potential … More scientific detail

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Proposal: A Pre-Meal Beet Juice “Cocktail” for Prevention and Control of Type 2 Diabetes

Dietary nitrate, richly supplied by green leafy vegetables and beet juice, aids production of protective nitric oxide, and is now thought to reduce risk for heart attack and stroke. This essay suggests that dietary nitrate may also decrease diabetes risk … More scientific detail

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Dietary Nitrate May Aid Prevention of Neovascular Age-related Macular Degeneration by Suppressing the Transcriptional Activity of Hypoxia-Inducible Factor-1 and Aiding Choroidal Perfusion

A high daily intake of spinach or collard greens has been linked to a considerable decrease in risk for age-related macular degeneration, chief cause of partial blindness in the elderly. Although the lutein content of these vegetables is thought to … More scientific detail

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Dietary Nitrate and Reductive Polyphenols May Potentiate the Vascular Benefit and Alleviate the Ulcerative Risk of Low-Dose Aspirin

Low-dose aspirin has tremendous protective potential; not only can it reduce risk for heart attack and stroke, but more recent evidence suggests it may notably reduce cancer mortality during long-term use. Nonetheless, it also sometimes provokes GI ulceration and bleeding … More scientific detail

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Zinc and Multi-Mineral Supplementation Should Mitigate the Pathogenic Impact of Cadmium Exposure

High-normal cadmium levels have recently emerged as a risk factor for vascular disease, cancer, osteoporosis, kidney disease, diabetes, and total mortality. This essay proposes that supplementing meals with zinc and multi-minerals can be expected to impede the absorption of dietary … More scientific detail

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Bilirubin and Phycocyanobilin vs. the Fifteen Leading Causes of Death

Recent studies demonstrate that the natural metabolite bilirubin functions physiologically to inhibit a primary source of the oxidative stress driving many health disorders – NADPH oxidase. A phytonutrient known as phycocyanobilin, richly supplied by spirulina, is a chemical relative of … More scientific detail

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Adjuvant Colorectal Cancer Treatment Strategies

This document cites a number of nutraceutical or drug measures that have potential for slowing the growth of colorectal cancer and/or improving its responsiveness to chemotherapy. Abstracts of scientific publications pertinent to these suggestions are appended.

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Adjuvant Melanoma Treatment Strategies

This document cites a number of nutraceutical or drug measures that have potential for slowing the growth of melanoma and/or improving its responsiveness to chemotherapy. Abstracts of scientific publications pertinent to these suggestions are appended.

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Adjuvant Pancreatic Cancer Treatment Strategies

This document cites a number of nutraceutical or drug measures that have potential for slowing the growth of prostate cancer and/or improving its responsiveness to chemotherapy. Abstracts of scientific publications pertinent to these suggestions are appended.

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Adjuvants of Potential Value in Multiple Myeloma Treatment

Despite the development of novel chemotherapy regimens which are prolonging life in many patients with multiple myeloma, long term prognosis remains poor owing to the onset of chemoresistance. However, a number of available drugs have the potential to render this … More scientific detail

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Epithelial Ovarian Cancer – Adjuvant Measures with Potential for Slowing Its Spread and Boosting or Restoring its Chemosensitivity

Epithelial ovarian cancer accounts for more deaths than any other gynecological cancer. If surgery fails to achieve a cure, chemotherapy is usually effective initially, but most cancers eventually evolve to resistance and progress. This essay discusses a number of nutraceuticals, … More scientific detail

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Adjuvant Prostate Cancer Treatment Strategies

This document cites a number of nutraceutical or drug measures that have potential for slowing the growth of prostate cancer and/or improving its responsiveness to chemotherapy. Abstracts of scientific publications pertinent to these suggestions are appended.

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Controlling Prostate Cancer Through Durable Inhibition of Androgen Receptor Activity

The great majority of prostate cancers remain dependent on effective activity of the androgen receptor – even cancers that no longer respond to androgen-antagonist measures and hence are characterized as “androgen-independent”. It may however prove feasible to durably inhibit androgen … More scientific detail

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Proposal for Ex Vivo Chemoadjuvant Testing

For cancers that can be biopsied, it is now feasible to assess their sensitivities to chemotherapy drugs in the laboratory, before chemotherapy is done. This can often help oncologists to choose agents capable of effectively controlling the cancer, while avoiding … More scientific detail

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Practical Strategies for Preserving Good Cognitive Function into Old Age

As people age, there is a tendency for cognitive ability to decline at least modestly, and, in many people, neurodegenerative disorders and/or strokes can bring on dementia. This article suggests a wide number of lifestyle strategies – involving dietary choices, … More scientific detail

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The Neuroinflammation and Loss of Hippocampal GABAergic Interneurons That Mediate Age-Related Decline in Cognitive Function May be Interdependent

This article discusses the neurological mechanisms which are suspected to bring on the cognitive decline associated with healthy aging – in particular, the mild brain inflammation associated with the chronic activation of microglial cells (neuroinflammation), and the die off of … More scientific detail

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A Role for Activated Microglia and Peroxynitrite in Lewy Body Disease – Implications for Prevention and Control

Parkinson’s disease and Lewy body dementia – a little-publicized disorder thought to be responsible for about 20% of clinical dementia – may be two aspects of the same underlying problem, Lewy body disease, characterized by aggregation of the protein alpha-synuclein … More scientific detail

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Taurine, A Natural LXRalpha, May Promote Amyloid Beta Clearance in the Brain

There is very recent evidence that the nutrient taurine can activate an intracellular receptor known as LXRalpha. Certain drugs capable of activating this receptor – not yet available clinically – are beneficial in rodent models of Alzheimer’s disease, largely because … More scientific detail

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Tributyrin May Have Practical Potential for Improving Cognition in Early Alzheimer’s Disease Via Inhibition of HDAC2

Recent research at MIT has determined that, in rodent models of Alzheimer’s dementia, the negative impact of amyloid beta exposure on neuronal function and new memory formation results largely from increased neuronal expression of an enzyme known as HDAC2 (histone … More scientific detail

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Memo: Arian Foster’s Whole-Food Vegan Diet May Protect Him from Trauma-Triggered Neurodegenerative Disorders

Professional football players, and other people whose professions may subject them to repeated moderate brain trauma, are now known to be at increased risk for neurogenerative disorders – particularly Alzheimer’s and ALS – during their retirement years. There is evidence … More scientific detail

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What are the best bets in the supplement field for delaying the onset of dementia, a.k.a. vascular disease or Alzheimers?

Supplements which boost vascular production of the protective hormone nitric oxide, which quell oxidative stress, and which suppress the activity of brain inflammatory cells should be useful for slowing age-related cognitive decline and preventing Alzheimers or stroke-induced dementia.  These can … More scientific detail

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I’ve heard that apple cider vinegar may aid weight loss; is there any validity to this, or is it just one of those “old wives’ tales”?

Believe it or not, a recent double-blind clinical study in Japan found that overweight people ingesting 2 tablespoons of apple cider vinegar daily (a drink of equal calorie content featuring lactic acid was used as a control) lost an average … More scientific detail

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What is insulin resistance, why does it occur, and why is it typically associated with high insulin levels?

Insulin has a prominent hormonal effect on skeletal muscle fibers, liver cells, and fat cells; in these tissues, it encourages uptake and discourages the release of blood sugar (glucose) and fats.  In other words, insulin promotes fuel storage. Insulin resistance … More scientific detail

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How does low IGF-I bioactivity decrease cancer risk?

. IGF-I (insulin-like growth factor-I) is often referred to as “the universal cancer promoter”.  This reflects the fact that a high proportion of the tissues most likely to give rise to cancer are sensitive to its growth factor activity.   In … More scientific detail

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