Author Archives: DWDLLC

Research by Mark McCarty and James DiNicolantonio Recognized by AAAS

On 24 Feb 2020, the American Association for the Advancement of Science (AAAS) issued a press release citing an article describing the work of CLF Founder, Mark McCarty, together with his co-author James DiNicolantonio, pointing the way toward a practical … More scientific detail

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Biliverdin/Phycocyanobilin, Glycine, High-Dose Folate, and Metformin/Berberine as Antidotes to Endotoxin

Sepsis is a leading cause of death in hospitalized patients who have developed infections with gram negative bacteria. A cell wall component in these bacteria, known as lipopolysaccharide or endotoxin, triggers this syndrome by strongly activating immune cells known as … More scientific detail

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Do GLP-1 and Glucagon Mediate Some of the Protection Afforded by Supplemental Glycine?

The amino acid glycine, when ingested in high daily doses, has a range of promising anti-inflammatory effects, reflecting its ability to activate receptors that permit the flux of chloride ions across cell membranes. Glycine is particularly protective to rodents fed … More scientific detail

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The Protection Conferred by Chelation Therapy in Post-MI Diabetics Might be Replicated by High-Dose Zinc Supplementation

A recent clinical trial funded by the NIH has concluded that, whereas i.v. chelation therapy is not beneficial for most patients who previously have suffered a heart attack, diabetics achieve a substantial reduction in mortality and risk for another heart … More scientific detail

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Nutraceutical and Drug Measures for Expanding the T Regulatory Lymphocyte Pool

Immune cells known as T regulatory lymphocytes exert anti-inflammatory effects and help to ward off autoimmune disorders such as rheumatoid arthritis, ulcerative colitis, SLE, and multiple sclerosis. They may also aid in the prevention and control of neurodegenerative conditions, atherosclerosis, … More scientific detail

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Response to Editorial: “Enough is Enough: Stop Wasting Money on Vitamin and Mineral Supplements”

This essay offers a vigorous response to a recent editorial in Annals of Internal Medicine that urged people to stop “wasting their money” on vitamin-mineral supplements. In fact, although most multi-vitamin-mineral supplements currently sold may offer little health benefit to … More scientific detail

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Potential Ghrelin-Mediated Benefits and Risks of Hydrogen Water

Ingestion of water saturated with molecular hydrogen (H2) has been widely studied in Japan recently as an antioxidant strategy. Although H2 has antioxidant potential, the elevations of H2 in blood achieved by ingesting hydrogen water are so modest and transient … More scientific detail

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A Vegan Diet of Modest Protein Content, by Down-Regulating Akt-mTORC1 Activity in Lymphocytes, May Aid Induction of T Regulatory Cells

Many autoimmune disorders – maladies such as rheumatoid arthritis, ulcerative colitis, and multiple sclerosis – were quite rare among sub-Saharan Africans in the middle of the last century, and also appear to have been comparatively rare in certain quasi-vegan Asian … More scientific detail

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“Failure to Thrive” as a Vegan – Could Supplemental Carninutrients Help?

Although whole-food vegan diets are notably health protective in many ways, some people who have tried vegan diets, even those informed enough to supplement with vitamin B12 (absent from vegan diets), claim that they gave up this attempt because they … More scientific detail

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GCN2 and FGF21 are Likely Mediators of the Protection from Cancer, Autoimmunity, Obesity, and Diabetes Afforded by Vegan Diets

Vegan diets of moderate protein content, when practiced throughout life, have been linked to a markedly decreased risk for many cancers, as well as for autoimmune disorders, obesity, and diabetes. Such diets also typically lower blood levels of the hormone … More scientific detail

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Memo: Carvedilol for Blood Pressure Control in Metabolic Syndrome and Type 2 Diabetes

“Metabolic syndrome” – typically associated with increased abdominal fat, elevated levels of triglycerides and insulin, low HDL cholesterol, and raised blood pressure – is a key cause of vascular disease, diabetes, and cancer. This syndrome is usually associated with increased … More scientific detail

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A Whole-Food Vegan Ketogenic Diet for Treatment of Cancer

Low-carbohydrate ketogenic diets may aid control of certain cancers by keeping glucose and insulin levels low throughout the day, and vegan diets of moderate protein content can decrease blood levels of insulin-like growth factor-I (IGF-I), a hormone which promotes proliferation … More scientific detail

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A Role for cAMP-Driven Transactivation of EGFR in Cancer Aggressiveness – Therapeutic Implications

A signaling molecule known as cyclic AMP (cAMP) is produced in many cancers, and makes them more aggressive. Adrenergic hormones (adrenaline, noradrenaline), as well as hormones produced by the pro-inflammatory cox-2 enzyme, boost cAMP production in many cancers. Hence, drugs … More scientific detail

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CK2 Inhibition May be a Key Mediator of the Cancer-Retardant Effects of Natural Flavones in Xenografted Nude Mice

An enzyme known as CK2 is highly active in a high proportion of aggressive cancers, and functions in numerous ways to make cancers more aggressive and harder to kill. Drugs which target this enzyme are currently being developed in hopes … More scientific detail

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Neurosupportive Potential of Creatine Orotate

This essay proposes that the supplement creatine orotate may work in multiple complementary ways to aid cognitive function, while protecting the brain from stroke, trauma, and neurodegenerative disorders, and also supporting efficient brain healing. It should do this by boosting … More scientific detail

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A Carbohydrate Concentration Regimen that Segregates Protein-Rich Foods into Low-Carb Meals May Represent a More Practical Way to Achieve the Healthspan Benefits Conferred by Calorie Restriction or Alternate-Day Fasting

Calorie restriction and alternate-day fasting boost healthspan and lifespan in rodents and other species, and can promote leanness, but are too rigorous for most people to stick with as a lifestyle. This essay reviews proposed alternative strategies that have the … More scientific detail

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Memo: Is Peroxynitrite a Mediator of Survival and Aggressive Growth in Pancreatic Adenocarcinoma?

Pancreatic adenocarcinomas tend to generate both superoxide and nitric oxide, and both of these factors aid the survival and spread of the cancer. This essay raises the possibility that a portion of this effect is mediated by peroxynitrite, which forms … More scientific detail

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Memo: PNC-27, a Peptide that Induces Necrosis Selectively in Cancer Cells

Cancer scientists at State University of New York have developed a protein that can punch holes in the walls of cancer cells, leading to their death. This phenomenon appears to be selective to cancer cells, and is more likely to … More scientific detail

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NADPH Oxidase as a Mediator of Calcium Oxalate Nephrolithiasis

The most common type of kidney stone is composed of calcium oxalate. Oxalate can act on the kidney tubules to induce oxidative stress via NADPH oxidase, and this plays a role in the promotion of stone formation. This explains why … More scientific detail

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Are Antioxidants Bad for Us? — A Response to Dr. Paul Offit

Pediatrician Dr. Paul Offit has been creating a bit of a stir with his new book, Do You Believe in Magic? The Sense and Nonsense of Alternative Medicine. Although many of the targets he takes on are no doubt worthy … More scientific detail

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Stroke Prevention in a Nutshell

A concise summary of lifestyle strategies for reducing your risk for stroke.

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Ambient Cadmium Importantly Up-Regulates Systemic Oxidative Stress

The most recent epidemiology on cadmium suggests that exposure to this toxic metal may be responsible for a high proportion of cases of breast and pancreatic cancer in people who have not experienced industrial cadmium exposure. It also suggests that … More scientific detail

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Phycocyanobilin from Spirulina — the Master Antioxidant

The chief source of oxidative stress in many health disorders is the NADPH oxidase complex; in many of these disorders, the oxidants produced by this complex either cause the syndrome, or at least make it worse. Although the natural metabolite … More scientific detail

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Interleukin-6 and Tumor Necrosis Factor-alpha, Which May Boost Homocysteine by Decreasing Hepatic S-Adenosylmethionine, May Mediate the Cardiovascular Risk Associated with Moderately Elevated Homocysteine

Although moderate elevations of the metabolite homocysteine (hcy) correlate with increased risk for heart attack and stroke, the failure of vitamin therapies which lower hcy to reduce vascular risk reveals that moderately elevated hcy per se does not cause heart … More scientific detail

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Practical Strategies for Suppressing Hypoxia-Inducible Factor Activity in Cancer Therapy

Anti-angiogenic strategies for controlling cancer – measures which slow cancer growth and spread by blocking the growth of new blood vessels required for tumor expansion – were initially considered to have great promise, but in practice have usually had only … More scientific detail

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Expression and/or Activity of the SVCT2 Ascorbate Transporter May be Decreased in Many Aggressive Cancers, Suggesting Potential Utility for Sodium Bicarbonate and Dehydroascorbic Acid in Cancer Therapy

Within cancer cells, vitamin C (ascorbate) performs the key function of controlling the activity of hypoxia-inducible factor-1 (HIF-1), a protein which helps cancer cells to thrive in low oxygen conditions and makes them much more aggressive. But there is evidence … More scientific detail

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Rationale for a Novel Nutraceutical Complex ‘K-Water: Potasssium Taurine Bicarbonate (PTB)

This essay proposes a nutraceutical water – “K-Water” – enriched with potassium bicarbonate and taurine, as a practical strategy for boosting daily intakes of potassium, taurine, and organic base. Despite its potassium content, the flavor of this water is almost … More scientific detail

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Isoflavones Made Simple – Genistein’s Agonist Activity for the Beta-Type Estrogen Receptor Mediates Their Health Benefits

The isoflavone phytochemicals in soy foods are often misleading refered to as “weak estrogens”. In fact, there are two types of estrogen receptors, ERalpha and ERbeta. ERalpha activity is responsible for the feminizing and pro-carcinogenic effects of estrogen, whereas ERbeta … More scientific detail

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Practical Strategies for Targeting NF-kappaB and NADPH Oxidase May Improve Survival During Lethal Influenza Epidemics

Perhaps surprisingly, the “killer” influenzas do not kill by the direct damaging impact of the flu virus on lung tissue, but rather by the over-exuberant immune response which such infections can evoke – effectively filling the lungs with fluid. An … More scientific detail

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Clinical Potential of Phycocyanobilin for Induction of T Regulatory Cells in the Management of Inflammatory Disorders

Recent studies indicate that the natural metabolite bilirubin, in addition to its profound antioxidant effect, also plays a key role in the induction of “T regulatory cells” – immune cells which play a key role in preventing or controlling autoimmunity … More scientific detail

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Dietary Saturate/Unsaturate Ratio as a Determinant of Adiposity

Diets in which the ratio of saturated to unsaturated fats is low – such as “Mediterranean” or most plant-based diets – tend to be associated with good muscle insulin sensitivity and a compensatory reduction of daily insulin secretion. Since insulin … More scientific detail

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Phycocyanobilin and Dietary Nitrate May Exert Natriuretic Effects That Suppress Production of Marinobufagenin

There is reason to suspect that both dietary nitrate – found in green leafy vegetables and beets – and the key phytochemical in spirulina, phycocyanobilin (PhyCB), can act on the kidneys to promote more efficient excretion of sodium, owing to … More scientific detail

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Marinobufagenin and Cyclic Strain May Activate Endothelial NADPH Oxidase, Contributing to the Adverse Impact of Salty Diets on Vascular and Cerebral Health

In people said to be “salt-sensitive”, a salty diet provokes a temporary fluid overload that is compensated by adrenal secretion of the hormone marinobufagenin (MBG). Although MBG acts on the kidneys to promote sodium and fluid excretion, it also acts … More scientific detail

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Minimizing the Cancer-Promotional Activity of Cox-2 as a Central Strategy in Cancer Prevention

Recent analyses of large controlled trials evaluating daily low-dose aspirin reveal that this strategy is associated with a notable reduction in cancer mortality. There is reason to suspect that this reflects aspirin’s ability to inhibit the pro-inflammatory enzyme cox-2. This … More scientific detail

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A “Mini-Fast with Exercise” Protocol for Fat Loss

Nesting sessions of moderate intensity aerobic exercise within 12-14 hour fasts is a logical and effective strategy for burning off stored fat; that’s because insulin and glucose levels remain low during and for some time after the exercise. If you … More scientific detail

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AMPK Activation – Protean Potential for Boosting Healthspan

Proposes that drugs, phytochemicals and foods capable of activating the enzyme AMP-activated Kinase (AMPK) may literally slow the aging process in some key respects – and potentiate the utility of carbohydrate-concentrated diets in this regard. Presents evidence that AMPK activation … More scientific detail

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Mini-Fast with Exercise — My Personal Experience

A straightforward, non-technical narrative which describes how the mini-fast with exercise strategy for leanness was developed.

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Induction of Hepatic Uncoupling Protein 2 May Mediate the “Metabolic Advantage” of Ketogenic Diets

An attempt to explain why people on very-low-carb ketogenic diets tend to lose weight and body fat faster than people eating higher carb diets of the exact same calorie content. Proposes that activation of thermogenic (heat generating) processes in the … More scientific detail

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Ketosis May Promote Brain Macroautophagy via Activation of Hypoxia-Inducible Factor-1

Suggests that a portion of the favorable impact of ketosis on brain function and health may reflect activation of the “cell cleansing” process known as macroautophagy in brain neurons. Proposes a mechanism whereby ketosis might achieve this.

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Could Carbohydrate -Concentrated Diets Mimic Calorie Restriction in Slowing the Aging Process?

A summary of the evidence supporting the utility of carbohydrate-concentrated diets for enhancing healthspan while promoting leanness. Delves into the molecular biology which may mediate these benefits.

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The NIA and Wisconsin Rhesus Calorie Restriction Studies – Some Comments

This article attempts to rationalize the contrasting results of the rhesus monkey calorie restriction longevity studies still in progress at the National Institutes of Aging and the Wisconsin National Primate Research Center. The “take home” lesson from this analysis is … More scientific detail

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A Safe Strategy for Control of Hyperalgesia – Boswellic Acids, Phycocyanobilin, and Salsalate

In states of chronic inflammation or nerve damage, nature often pulls a cruel trick by boosting the sensitivy of the nervous system to painful stimuli – a phenomenon known as hyperalgesia. NSAIDS and opiates are often used to treat hyperalgesia, … More scientific detail

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Vaccination with Heat-Shocked Mononuclear Cells as a Strategy for Treating Neurodegenerative Disorders Driven by Microglial Inflammation

Proteins produced in heat-stressed cells, known as heat-shock proteins, can promote the activation of a type of immune cell – T regulatory lymphocytes – that functions physiologically to suppress inflammation. By exposing human blood cells to a survivable heat stress … More scientific detail

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β-Boswellic Acid, A Safe and Clinically Effective Inhibitor of Prostaglandin E Synthase-1, Has Potential for Prevention of Cancer, Alzheimer’s Disease, and Vascular Disorders, and for Control of Inflammatory Pain

Frankincense, rich in compounds known as boswellic acids, is a natural tree resin extract that has long been used in Ayurvedic medicine for treatment of inflammation. Recent research suggests that its utility in this regard reflects the ability of beta-boswellic … More scientific detail

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Low-Fat, Low-Salt, Whole-Food Vegan – Staying Lean and Healthy into Ripe Old Age

A whole-food plant-based diet, relatively low in fat and added salt, has tremendously versatile potential for health protection. This monograph sets forth the scientific evidence which suggests that this strategy can prevent or stop the progression of vascular disease; prevent … More scientific detail

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Overview of Macrophage Activating Factor and the Nagalase Assay – Potential for Control of Micrometastatic or Early Primary Cancer

This essay reviews the evidence currently available on macrophage activated factor (GcMAF) as a treatment for cancer, and on serum nagalase as a putatively universal marker for cancer. Studies by Yamamoto and colleagues suggest that, when cancer is in a … More scientific detail

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Injections of Macrophage Activating Factor May Have the Potential to Cure Cancer Patients with Minimal Residual Disease – and Now Can be Self-Administered by Patients

There is now strong reason to suspect that a natural protein, made in our bodies to boost the microbe- and cancer-fighting abilities of immune cells known as macrophages, can help to cure cancer when injected repeatedly by cancer patients who … More scientific detail

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Our Expanded Mission

In 2010, this website began when I realized that the practice of concentrating one’s carbohydrate intake into one meal daily — a practice first proposed by the Heller’s in their popular “Carbohydrate Addicts Diet” – might not only represent a … More scientific detail

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Jeremy Stone

Jeremy J. Stone (1935-2017) was President of Federation of American Scientists (FAS) (1970-2000), Catalytic Diplomacy (1999-2017), and Catalytic Longevity (2009-2017). For his bio, as provided in Wikipedia, go here. For his work in foreign policy, including two memoirs, visit www.catalytic-diplomacy.org. … More scientific detail

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Mark F. McCarty

Mark McCarty was born in Texas in 1951, but grew up in southern California, obtaining his undergraduate education in biochemistry at UC San Diego, Revelle College, graduating magna cum laude. He commenced his medical education by enrolling at UC San … More scientific detail

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