A Role for Activated Microglia and Peroxynitrite in Lewy Body Disease – Implications for Prevention and Control

Parkinson’s disease and Lewy body dementia – a little-publicized disorder thought to be responsible for about 20% of clinical dementia – may be two aspects of the same underlying problem, Lewy body disease, characterized by aggregation of the protein alpha-synuclein into intraneuronal inclusions known as Lewy bodies. This article proposes that inflammatory activation of brain cells known as microglia, and the highly toxic pro-oxidant compound peroxynitrite, produced by these activated microglia, may collaborate to induce and sustain Lewy body disease. Various antioxidant and anti-inflammatory nutraceuticals, drugs and lifestyle measures are discussed which have potential for scavenging peroxynitrite and dampening microglial inflammation.

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