Monthly Archives: February 2014

Do GLP-1 and Glucagon Mediate Some of the Protection Afforded by Supplemental Glycine?

The amino acid glycine, when ingested in high daily doses, has a range of promising anti-inflammatory effects, reflecting its ability to activate receptors that permit the flux of chloride ions across cell membranes. Glycine is particularly protective to rodents fed … More scientific detail

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The Protection Conferred by Chelation Therapy in Post-MI Diabetics Might be Replicated by High-Dose Zinc Supplementation

A recent clinical trial funded by the NIH has concluded that, whereas i.v. chelation therapy is not beneficial for most patients who previously have suffered a heart attack, diabetics achieve a substantial reduction in mortality and risk for another heart … More scientific detail

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Nutraceutical and Drug Measures for Expanding the T Regulatory Lymphocyte Pool

Immune cells known as T regulatory lymphocytes exert anti-inflammatory effects and help to ward off autoimmune disorders such as rheumatoid arthritis, ulcerative colitis, SLE, and multiple sclerosis. They may also aid in the prevention and control of neurodegenerative conditions, atherosclerosis, … More scientific detail

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Response to Editorial: “Enough is Enough: Stop Wasting Money on Vitamin and Mineral Supplements”

This essay offers a vigorous response to a recent editorial in Annals of Internal Medicine that urged people to stop “wasting their money” on vitamin-mineral supplements. In fact, although most multi-vitamin-mineral supplements currently sold may offer little health benefit to … More scientific detail

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Potential Ghrelin-Mediated Benefits and Risks of Hydrogen Water

Ingestion of water saturated with molecular hydrogen (H2) has been widely studied in Japan recently as an antioxidant strategy. Although H2 has antioxidant potential, the elevations of H2 in blood achieved by ingesting hydrogen water are so modest and transient … More scientific detail

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A Vegan Diet of Modest Protein Content, by Down-Regulating Akt-mTORC1 Activity in Lymphocytes, May Aid Induction of T Regulatory Cells

Many autoimmune disorders – maladies such as rheumatoid arthritis, ulcerative colitis, and multiple sclerosis – were quite rare among sub-Saharan Africans in the middle of the last century, and also appear to have been comparatively rare in certain quasi-vegan Asian … More scientific detail

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“Failure to Thrive” as a Vegan – Could Supplemental Carninutrients Help?

Although whole-food vegan diets are notably health protective in many ways, some people who have tried vegan diets, even those informed enough to supplement with vitamin B12 (absent from vegan diets), claim that they gave up this attempt because they … More scientific detail

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GCN2 and FGF21 are Likely Mediators of the Protection from Cancer, Autoimmunity, Obesity, and Diabetes Afforded by Vegan Diets

Vegan diets of moderate protein content, when practiced throughout life, have been linked to a markedly decreased risk for many cancers, as well as for autoimmune disorders, obesity, and diabetes. Such diets also typically lower blood levels of the hormone … More scientific detail

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Memo: Carvedilol for Blood Pressure Control in Metabolic Syndrome and Type 2 Diabetes

“Metabolic syndrome” – typically associated with increased abdominal fat, elevated levels of triglycerides and insulin, low HDL cholesterol, and raised blood pressure – is a key cause of vascular disease, diabetes, and cancer. This syndrome is usually associated with increased … More scientific detail

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A Whole-Food Vegan Ketogenic Diet for Treatment of Cancer

Low-carbohydrate ketogenic diets may aid control of certain cancers by keeping glucose and insulin levels low throughout the day, and vegan diets of moderate protein content can decrease blood levels of insulin-like growth factor-I (IGF-I), a hormone which promotes proliferation … More scientific detail

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A Role for cAMP-Driven Transactivation of EGFR in Cancer Aggressiveness – Therapeutic Implications

A signaling molecule known as cyclic AMP (cAMP) is produced in many cancers, and makes them more aggressive. Adrenergic hormones (adrenaline, noradrenaline), as well as hormones produced by the pro-inflammatory cox-2 enzyme, boost cAMP production in many cancers. Hence, drugs … More scientific detail

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CK2 Inhibition May be a Key Mediator of the Cancer-Retardant Effects of Natural Flavones in Xenografted Nude Mice

An enzyme known as CK2 is highly active in a high proportion of aggressive cancers, and functions in numerous ways to make cancers more aggressive and harder to kill. Drugs which target this enzyme are currently being developed in hopes … More scientific detail

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Neurosupportive Potential of Creatine Orotate

This essay proposes that the supplement creatine orotate may work in multiple complementary ways to aid cognitive function, while protecting the brain from stroke, trauma, and neurodegenerative disorders, and also supporting efficient brain healing. It should do this by boosting … More scientific detail

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