Monthly Archives: May 2013

Phycocyanobilin from Spirulina — the Master Antioxidant

The chief source of oxidative stress in many health disorders is the NADPH oxidase complex; in many of these disorders, the oxidants produced by this complex either cause the syndrome, or at least make it worse. Although the natural metabolite … More scientific detail

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Interleukin-6 and Tumor Necrosis Factor-alpha, Which May Boost Homocysteine by Decreasing Hepatic S-Adenosylmethionine, May Mediate the Cardiovascular Risk Associated with Moderately Elevated Homocysteine

Although moderate elevations of the metabolite homocysteine (hcy) correlate with increased risk for heart attack and stroke, the failure of vitamin therapies which lower hcy to reduce vascular risk reveals that moderately elevated hcy per se does not cause heart … More scientific detail

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Practical Strategies for Suppressing Hypoxia-Inducible Factor Activity in Cancer Therapy

Anti-angiogenic strategies for controlling cancer – measures which slow cancer growth and spread by blocking the growth of new blood vessels required for tumor expansion – were initially considered to have great promise, but in practice have usually had only … More scientific detail

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Expression and/or Activity of the SVCT2 Ascorbate Transporter May be Decreased in Many Aggressive Cancers, Suggesting Potential Utility for Sodium Bicarbonate and Dehydroascorbic Acid in Cancer Therapy

Within cancer cells, vitamin C (ascorbate) performs the key function of controlling the activity of hypoxia-inducible factor-1 (HIF-1), a protein which helps cancer cells to thrive in low oxygen conditions and makes them much more aggressive. But there is evidence … More scientific detail

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Rationale for a Novel Nutraceutical Complex ‘K-Water: Potasssium Taurine Bicarbonate (PTB)

This essay proposes a nutraceutical water – “K-Water” – enriched with potassium bicarbonate and taurine, as a practical strategy for boosting daily intakes of potassium, taurine, and organic base. Despite its potassium content, the flavor of this water is almost … More scientific detail

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Isoflavones Made Simple – Genistein’s Agonist Activity for the Beta-Type Estrogen Receptor Mediates Their Health Benefits

The isoflavone phytochemicals in soy foods are often misleading refered to as “weak estrogens”. In fact, there are two types of estrogen receptors, ERalpha and ERbeta. ERalpha activity is responsible for the feminizing and pro-carcinogenic effects of estrogen, whereas ERbeta … More scientific detail

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Practical Strategies for Targeting NF-kappaB and NADPH Oxidase May Improve Survival During Lethal Influenza Epidemics

Perhaps surprisingly, the “killer” influenzas do not kill by the direct damaging impact of the flu virus on lung tissue, but rather by the over-exuberant immune response which such infections can evoke – effectively filling the lungs with fluid. An … More scientific detail

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Clinical Potential of Phycocyanobilin for Induction of T Regulatory Cells in the Management of Inflammatory Disorders

Recent studies indicate that the natural metabolite bilirubin, in addition to its profound antioxidant effect, also plays a key role in the induction of “T regulatory cells” – immune cells which play a key role in preventing or controlling autoimmunity … More scientific detail

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Dietary Saturate/Unsaturate Ratio as a Determinant of Adiposity

Diets in which the ratio of saturated to unsaturated fats is low – such as “Mediterranean” or most plant-based diets – tend to be associated with good muscle insulin sensitivity and a compensatory reduction of daily insulin secretion. Since insulin … More scientific detail

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Phycocyanobilin and Dietary Nitrate May Exert Natriuretic Effects That Suppress Production of Marinobufagenin

There is reason to suspect that both dietary nitrate – found in green leafy vegetables and beets – and the key phytochemical in spirulina, phycocyanobilin (PhyCB), can act on the kidneys to promote more efficient excretion of sodium, owing to … More scientific detail

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Marinobufagenin and Cyclic Strain May Activate Endothelial NADPH Oxidase, Contributing to the Adverse Impact of Salty Diets on Vascular and Cerebral Health

In people said to be “salt-sensitive”, a salty diet provokes a temporary fluid overload that is compensated by adrenal secretion of the hormone marinobufagenin (MBG). Although MBG acts on the kidneys to promote sodium and fluid excretion, it also acts … More scientific detail

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Minimizing the Cancer-Promotional Activity of Cox-2 as a Central Strategy in Cancer Prevention

Recent analyses of large controlled trials evaluating daily low-dose aspirin reveal that this strategy is associated with a notable reduction in cancer mortality. There is reason to suspect that this reflects aspirin’s ability to inhibit the pro-inflammatory enzyme cox-2. This … More scientific detail

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