Monthly Archives: April 2013

A “Mini-Fast with Exercise” Protocol for Fat Loss

Nesting sessions of moderate intensity aerobic exercise within 12-14 hour fasts is a logical and effective strategy for burning off stored fat; that’s because insulin and glucose levels remain low during and for some time after the exercise. If you … More scientific detail

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AMPK Activation – Protean Potential for Boosting Healthspan

Proposes that drugs, phytochemicals and foods capable of activating the enzyme AMP-activated Kinase (AMPK) may literally slow the aging process in some key respects – and potentiate the utility of carbohydrate-concentrated diets in this regard. Presents evidence that AMPK activation … More scientific detail

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Mini-Fast with Exercise — My Personal Experience

A straightforward, non-technical narrative which describes how the mini-fast with exercise strategy for leanness was developed.

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Induction of Hepatic Uncoupling Protein 2 May Mediate the “Metabolic Advantage” of Ketogenic Diets

An attempt to explain why people on very-low-carb ketogenic diets tend to lose weight and body fat faster than people eating higher carb diets of the exact same calorie content. Proposes that activation of thermogenic (heat generating) processes in the … More scientific detail

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Ketosis May Promote Brain Macroautophagy via Activation of Hypoxia-Inducible Factor-1

Suggests that a portion of the favorable impact of ketosis on brain function and health may reflect activation of the “cell cleansing” process known as macroautophagy in brain neurons. Proposes a mechanism whereby ketosis might achieve this.

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Could Carbohydrate -Concentrated Diets Mimic Calorie Restriction in Slowing the Aging Process?

A summary of the evidence supporting the utility of carbohydrate-concentrated diets for enhancing healthspan while promoting leanness. Delves into the molecular biology which may mediate these benefits.

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The NIA and Wisconsin Rhesus Calorie Restriction Studies – Some Comments

This article attempts to rationalize the contrasting results of the rhesus monkey calorie restriction longevity studies still in progress at the National Institutes of Aging and the Wisconsin National Primate Research Center. The “take home” lesson from this analysis is … More scientific detail

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A Safe Strategy for Control of Hyperalgesia – Boswellic Acids, Phycocyanobilin, and Salsalate

In states of chronic inflammation or nerve damage, nature often pulls a cruel trick by boosting the sensitivy of the nervous system to painful stimuli – a phenomenon known as hyperalgesia. NSAIDS and opiates are often used to treat hyperalgesia, … More scientific detail

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Vaccination with Heat-Shocked Mononuclear Cells as a Strategy for Treating Neurodegenerative Disorders Driven by Microglial Inflammation

Proteins produced in heat-stressed cells, known as heat-shock proteins, can promote the activation of a type of immune cell – T regulatory lymphocytes – that functions physiologically to suppress inflammation. By exposing human blood cells to a survivable heat stress … More scientific detail

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β-Boswellic Acid, A Safe and Clinically Effective Inhibitor of Prostaglandin E Synthase-1, Has Potential for Prevention of Cancer, Alzheimer’s Disease, and Vascular Disorders, and for Control of Inflammatory Pain

Frankincense, rich in compounds known as boswellic acids, is a natural tree resin extract that has long been used in Ayurvedic medicine for treatment of inflammation. Recent research suggests that its utility in this regard reflects the ability of beta-boswellic … More scientific detail

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Low-Fat, Low-Salt, Whole-Food Vegan – Staying Lean and Healthy into Ripe Old Age

A whole-food plant-based diet, relatively low in fat and added salt, has tremendously versatile potential for health protection. This monograph sets forth the scientific evidence which suggests that this strategy can prevent or stop the progression of vascular disease; prevent … More scientific detail

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Overview of Macrophage Activating Factor and the Nagalase Assay – Potential for Control of Micrometastatic or Early Primary Cancer

This essay reviews the evidence currently available on macrophage activated factor (GcMAF) as a treatment for cancer, and on serum nagalase as a putatively universal marker for cancer. Studies by Yamamoto and colleagues suggest that, when cancer is in a … More scientific detail

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Injections of Macrophage Activating Factor May Have the Potential to Cure Cancer Patients with Minimal Residual Disease – and Now Can be Self-Administered by Patients

There is now strong reason to suspect that a natural protein, made in our bodies to boost the microbe- and cancer-fighting abilities of immune cells known as macrophages, can help to cure cancer when injected repeatedly by cancer patients who … More scientific detail

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Our Expanded Mission

In 2010, this website began when I realized that the practice of concentrating one’s carbohydrate intake into one meal daily — a practice first proposed by the Heller’s in their popular “Carbohydrate Addicts Diet” – might not only represent a … More scientific detail

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