Monthly Archives: February 2013

Serum Bilirubin May Serve as a Marker for Increased Heme Oxygenase Activity and Inducibility in Tissues – a Rationale for the Versatile Health Protection Associated with Elevated Plasma Bilirubin

Elevated serum levels of the antioxidant bilirubin tend to be associated with lower risk for cardiovascular disease and many other disorders, but people who have elevated bilirubin owing to their expression of a low-activity form of an enzyme that aids … More scientific detail

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Targeting Adipocytes in Metabolic Syndrome – Spirulina and Salsalate May Complement the Benefits of PPARgamma Agonists

Metabolic syndrome, an important cause of vascular disease and type 2 diabetes, and a risk factor for cancer, is driven by an inflammatory state that arises in overstuffed fat cells (adipocytes). The diabetes drug pioglitazone (Actos) is useful for dampening … More scientific detail

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Strategies for Controlling Serum Amyloid A, a Key Mediator of the Impact of Systemic Inflammation on Cardiovascular Disease

Although a systemic inflammatory state associated with elevated C-reactive protein (CRP) is clearly associated with increased cardiovascular risk, CRP per se does not appear to mediate this association. There is better reason to suspect that elevated serum amyloid A – … More scientific detail

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Folate Deprivation/Antagonist Therapy for Early Stage Prostate Cancer

Prostate epithelium, and some early prostate cancers, appear to require higher concentrations of folic acid than most other tissues to support a maximal rate of cellular multiplication. Therefore, a low-folate diet and/or low doses of the folate antagonist methotrexate may … More scientific detail

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High-Dose Statin Flash-Potentiation of Cancer Chemotherapy

Concentrations of statins much higher than those achieved clinically have potentiated the cancer-killling efficacy of many cytotoxic chemotherapeutic agents in cell culture studies or mice, but would be toxic if sustained in humans. This essay proposes that administration of very-high-dose … More scientific detail

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